Atmospheric Pressure Mass Spectrometry

MALDI Atmospheric Pressure Mass Spectrometry

The MassTech™ Atmospheric-Pressure Matrix-Assisted Laser-Desorption Ionisation (AP-MALDI) source enables mass spectrometers fitted with an electrospray or nanospray source to have the additional capability of MALDI. It is called AP-MALDI because, unlike vacuum MALDI, ionisation takes place under atmospheric conditions. This provides several important advantages including convenience, speed of analysis, simplicity of operation and cost. 


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Leaders in the design and production of AP-MALDI sources


  • Change between MALDI and ESI/nanospray in minutes. Calibrate in ESI and switch to MALDI without recalibration. Sample plates loaded in seconds as there is no waiting for vacuum to be achieved - see a video of the installation of an AP-MALDI source below
  • Fast imaging, 2.5 hours to image a 1 cm x 1cm section when coupled with latest fast scanning mass spectrometers ( 12Hz or better)
  • New high resolution X-Y stage for 5 micron spot size
  • MS-MS and MSn data (if instrumental capabilities permit) from a MALDI source for enhanced sequencing information at a fraction of the cost of a TOF-TOF instrument
  • Robotic control of MALDI targets with CCTV point-and-click visual alignment checking for confidence in operation
  • Imaging acquisition and processing software for MALDI imaging of tissues and other surfaces
  • Can be fitted to instruments from Thermo, Agilent, Bruker and Sciex
  • Custom sources on request

Lipids in mouse brainLipids in mouse brain

Lipids in mouse brain. Data achieved on LTQ-Orbitrap at 10 micron lateral resolution. Data courtesy of Dr. Gilles Frache Luxembourg Institute of Science and Technology